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Rabies is responsible for approximately 60,000,000 preventable deaths each year

 

What is Rabies?

  • A vaccine-preventable zoonotic viral disease caused by Rabies lyssavirus – a neurotropic virus of the Rhabdoviridae family
  • Widespread disease occurring in more than 150 countries and territories, mainly in Asia and Africa

 

Rabies is still present and almost always fatal when left untreated.

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Typical carnivore host reservoirs for Rabies Virus (RABV) are: Africa: domestic dog (Canis lupus familiaris), jackals (Canis adustus and C. mesomelas), mongoose (Herpestes spp.); Middle East and Asia: domestic dog (Canis lupus familiaris), red fox (Vulpes vulpes), ferret badger (Melogale moschata), golden jackals (Canis aureus); Europe: red fox (Vulpes vulpes), raccoon dog (Nyctereutes procyonoides); North America: raccoon (Procyon lotor), grey fox (Urocyon cinereoargenteus), striped skunk (Mephitis mephitis), coyote (Canis latrans); South America: domestic dog (Canis lupus familiaris), crab-eating fox (Cerdocyon  thous), marmoset (Callithrix jacchus); Caribbean islands: domestic dog (Canis lupus familiaris), small Indian mongoose (Herpestes auropunctatus); Eurasian and American arctic and subarctic regions: arctic fox (Alopex lagopus); Within one geographic region different independent infection cycles may occur simultaneously, as in the Americas where raccoons, skunks, red foxes, grey foxes, coyotes and arctic foxes are primary reservoir hosts.

 

Did You Know?

60k
Rabies causes 60,000 deaths annually, but it can be prevented by vaccination
Dog
Up to 99% of human rabies cases are transmitted by dogs
Syringe
Rabies vaccination can provide pre-exposure prophylaxis (PrEP) for protection before exposure to rabies In a global survey of travel clinics, nearly 500 travelers per year were in need of rabies PEP. Potential rabies exposure was more common than infection with hepatitis A or typhoid fever, which affected 20 and 40 travelers per year, respectively.
Bottle
Post-exposure prophylaxis (PEP) aims to stop the onset of rabies after exposure to the virus
Rabies: 100 per cent fatal, 100 per cent preventable

Learn more about Rabies prevention

how it spreads

 

How is Rabies Transmitted?

  • Rabies is transmitted in the saliva of rabid animals and generally enters the body when individuals are exposed to virus-laden saliva via scratches or bites
  • Rabid animals may not look sick and may act in surprising, unpredictable ways

 

Animals that Transmit Rabies

Infected dogs cause up to 99% of human deaths from rabies worldwide.

  • In the Americas, bats are now the major cause of human deaths from rabies as dog-mediated transmission has mostly been broken in this region
  • Bat rabies represents an emerging public health threat in Australia and Western Europe
  • Other common carriers include Raccoon, Monkey, Fox, Mongoose, Cat and Skunk

 

Common Carriers

Dog

Dog

Racoon

Raccoon

Cat

Cat

Fox

Fox

Monkey

Monkey

Bat

Bat

Mongoose

Mongoose

Skunk

Skunk

 

In a study that assessed travelers’ exposure to animals, the most frequently reported bites were made by dogs (57.1%), followed by monkeys (25.7%) and cats (10.6%)

 

Who is at Risk?

1. WHO recommends consideration of pre-exposure prophylaxis (PrEP) for outdoor travellers to remote areas with a high rabies exposure, where immediate medical care may be limited.

In a global survey of travel clinics, nearly 500 travelers per year were in need of rabies PEP. Potential rabies exposure was more common than infection with hepatitis A or typhoid fever, which affected 20 and 40 travelers per year, respectively.
 

2. PrEP immunisation is recommended for people in certain high-risk occupations such as:

  • laboratory workers handling live rabies and rabies-related (lyssavirus) viruses; 
  • people (such as animal disease control staff and wildlife rangers) whose professional or personal activities might bring them into direct contact with bats, carnivores, or other mammals that may be infected.

3. Immunisation should also be considered for children living in, or visiting remote areas with a high rabies exposure. As they play with animals, they may receive more severe bites, or may not report bites.

 

Clinical Manifestations of Rabies

  • When infected with rabies, progressive and fatal encephalitis develops as the virus spreads to the central nervous system

  • The incubation period of rabies is considered one of the most variable among viral infections of the central nervous system: it typically lasts between 20 to 90 days but can range from a few days to a year or more

  • This variability depends upon factors such as location of virus entry and viral load

  • Initial symptoms include a fever with pain and unusual or unexplained tingling, pricking, or paraesthesia at the wound site

  • Once rabies symptoms appear, survival is extremely rare

Furious rabies

Paralytic rabies

~80% of rabies cases

~20% of rabies cases

Characterised by signs of CNS irritation:

  • Hyperactivity

  • Excitable behaviour

  • Hydrophobia

  • Aerophobia

Characterised by weakness and paralysis:

  • Often misdiagnosed, leading to disease under-reporting

Rapidly progressing disease, with death due to cardio-respiratory arrest

Slower disease progression

 

With just one bite or scratch, rabies can end a trip and possibly a life, but with a rabies vaccine you can prevent it.

Learn more